Repositorio Universidad del Cauca

ESTEROIDE ORAL VERSUS ESTEROIDE ENDOVENOSO PARA EL TRATAMIENTO DE OFTALMOPATÍA TIROIDEA

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dc.contributor.author Maya Ruiz, Daira Elizabeth
dc.date.accessioned 2018-11-26T22:36:12Z
dc.date.available 2018-11-26T22:36:12Z
dc.date.issued 2013
dc.identifier.citation Vancouver en_US
dc.identifier.uri http://repositorio.unicauca.edu.co:8080/xmlui/handle/123456789/119
dc.description.abstract Intravenous steroid therapy versus oral steroid for thyroid-associated ophthalmopathy BACKGROUND:Thyroid-associated ophthalmopathy (TO) is the most common extra thyroid manifestation and the most important of autoimmune thyroid disease. The use of oral or intravenous steroids administration is one of the strategies for treating patients with OT. OBJETIVES: To evaluate the effect of intravenous steroid adminstration compared versus orally administered in the treatment of TO. SEARCH STRATEGY: Clinical trials were identified in the literature from 1980 to junary 2013 comparing the use of intravenous versus oral steroid in the treatment of patients with TO. SELECTION CRITERIA: Any clinical trial comparing the use of oral versus intravenous steroid in the treatment of patients with TO. Studies were selected independently by the reviewers MAIN RESULTS: We found four clinical trials comparing the use of intravenous versus oral steroid in the management of TO. All patients receiving steroid regardless of method of administration have improvement with respect to their condition before the start of treatment. Three studies show statistically significant differences in the improvement of the parameters evaluated in favor of receiving the steroid intravenously. (P = 0.01 ˂ - ˂ p = 0.001 - p = 0.0001) steroids are generally well tolerated, but adverse effects are more frequent in patients receiving oral therapy. (p ˂ 0.0001). Three of the studies used the same doses and schedule for administration of intravenous methylprednisolone. For oral administration each study presents a different scheme. AUTHOR’S CONCLUSIONS: The evaluation of patients who receive steroids for the management of thyroid ophthalmopathy should be comprehensive and in conjunction with ophthalmology. Patients receiving steroid have a moderate or severe classification and activity scale score greater than 4. TO patients receiving intravenous methylprednisolone therapy, compared to those treated with oral prednisone or methylprednisolone have a greater percentage improvement in the TO and this improvement was also observed earlier form with fewer adverse events. en_US
dc.description.sponsorship Departamento de Medicina Interna, Universidad del Cauca. Popayán. en_US
dc.language.iso es en_US
dc.subject Oftalmopatia Tiroidea en_US
dc.subject Esteroides en_US
dc.title ESTEROIDE ORAL VERSUS ESTEROIDE ENDOVENOSO PARA EL TRATAMIENTO DE OFTALMOPATÍA TIROIDEA en_US
dc.type Thesis en_US


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