Repositorio Universidad del Cauca

ANTIBIOTICOS NO CARBAPENEMICOS PARA EL MANEJO DE INFECCIONES POR GRAM NEGATIVOS PRODUCTORES DE BETALACTAMASAS DE ESPECTRO EXTENDIDO EN POBLACION ADULTA NO VIH.

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dc.contributor.author Agredo, Diana Karina
dc.contributor.author Vargas Uricoechea, Hernando
dc.date.accessioned 2018-11-27T14:52:08Z
dc.date.available 2018-11-27T14:52:08Z
dc.date.issued 2014
dc.identifier.citation Vancouver en_US
dc.identifier.uri http://repositorio.unicauca.edu.co:8080/xmlui/handle/123456789/127
dc.description.abstract Background: Cryptococcal meningitis is the most common worldwide opportunistic infection whose incidence and mortality are related to the control of HIV and the availability of antiretroviral therapy, with a mortality of 20% with therapy and close to 100% without specific therapy. In middle and low income no access to these first-line therapies. To know the effectiveness of alternative therapies more available as it is, amphotericin B and fluconazole in induction therapy. Methods: A search was conducted in the PubMed database, meta-analyzes, systematic reviews and controlled clinical trials, in English, published between 1980 and April 2014 were included, whose primary objective was to evaluate the efficacy of antifungal therapy combined with amphotericin B and fluconazole against other schemes available in the induction treatment of Cryptococcal meningitis in adults, HIV. Results: Five trials were included, a total of 629 patients. Three studies compared amphotericin B+5-Flucytosine versus amphotericin B + Fluconazole, two of them become negative CSF was greater with the combination 5-Flucytosine Amphotericin B, P <0.05. Amphotericin B + Fluconazole showed CSF sterilization rate increased compared to monotherapy with amphotericin B. No studies found no association of the second therapy toxicity. One study found decreased risk of death at 70 days with the combination of amphotericin B plus 5-Flucytosine, P <0.04. Conclusions: Combination therapy with amphotericin B plus 5-Flucytosine therapy remains the earliest fungicidal activity, with an impact on mortality is not fully established. Alternative therapies as more fluconazole doses amphotericin B should be considered monotherapy with amphotericin B in areas where the availability of 5-Flucytosine is limited inasmuch as they do not increase the toxicity and rate of CSF sterilization is greater than monotherapy with Amphotericin B. en_US
dc.description.sponsorship Departamento de Medicina Interna, Universidad del Cauca. Popayán. en_US
dc.language.iso es en_US
dc.subject Anfotericina B en_US
dc.subject Fluconazol en_US
dc.subject Meningitis Criptococo en_US
dc.subject Terapia Combinada en_US
dc.title ANTIBIOTICOS NO CARBAPENEMICOS PARA EL MANEJO DE INFECCIONES POR GRAM NEGATIVOS PRODUCTORES DE BETALACTAMASAS DE ESPECTRO EXTENDIDO EN POBLACION ADULTA NO VIH. en_US
dc.type Thesis en_US


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